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Osteocytes undergoconsiderable shrinkage during routine slidepreparation, revealingempty lacunaewithasmall nucleus attached to theirwalls. lethality) helps establish a rank orderof the toxic effects manifested as the dose increases

lethality) helps establish a rank orderof the toxic effects manifested as the dose increases.

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If the rodent is tame,simply cupping it in the palm of a hand is ideal. This condition usually occurs in casesof serious insults to the stomach, such as gastroduodenalsurgery, caustic ingestion, or gastric volvulus. With the help ofATP-dependent proton pum ps, protons are transportedthrough the ruffled border, generatingalowpH (4 to 5) in themicroenvironment ofthe resorption bay. If lymphoid hyperplasia is noted on double-contrastbarium studies in patients with chronic H

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She also complains of abdominal pain,nausea and occasional vomiting. The second method was thermal denaturationscanning ?uorimetry, where the binding to a small molecule is detected because itincreases the protein’s thermal stability as measured by the tendency of a ? uores-cent dye to bind the exposed hydrophobic core of the unfolded protein

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This electron micrograph of a ribbon synapse from a mouse cochlear hair cell shows the ribbon protein complex with attachedsynaptic vesicles. Journal of theAmerican Medical Association, 284, 2997–2998. Interestingly, the histone deacetylase SIRT1 canalso localizes into the PML-NBs and reduce the acetylation of p53 at Lys382 andthereby antagonize the induction of p53 activity [216, 217]

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